Table 1 The parameters for fitted survival curves

Bortezomib group

 Vd

PFS

Log-normal: meanlog = 1.97; sdlog = 1.07

[7, 9, 26,27,28,29]

OS

Weibull: shape = 1.10; scale = 51.11

 DVd

HR of PFS

0.31 (0.25 – 0.40)

[7, 9]

HR of OS

0.74 (0.59 – 0.92)

 SVd

HR of PFS

0.70 (0.53 – 0.93)

[26]

HR of OS

0.84 (0.57 – 1.23)

 PVd

HR of PFS

0.61 (0.49 – 0.77)

[27]

HR of OS

0.98 (0.73 – 1.32)

 Kd

HR of PFS

0.53 (0.44 – 0.60)

[28]

HR of OS

0.79 (0.65 – 0.96)

 PanVd

HR of PFS

0.63 (0.52 – 0.76)

[29]

HR of OS

0.87 (0.69 – 1.10)

Lenalidomide group

 Rd

PFS

Gompertz: shape = −0.011; sdlog = 0.049

[6, 8, 11, 30,31,32]

OS

Log-normal: meanlog = 3.77; sdlog = 1.29

 ERD

HR of PFS

0.72 (0.60 – 0.87)

[8, 11]

HR of OS

0.82 (0.68 – 1.00)

 KRd

HR of PFS

0.66 (0.55 – 0.78)

[30]

HR of OS

0.79 (0.67 – 0.94)

 IxaRd

HR of PFS

0.74 (0.59 – 0.94)

[31]

HR of OS

0.94 (0.78 – 1.12)

 DRd

HR of PFS

0.44 (0.35 – 0.55)

[6]

HR of OS

0.73 (0.58 – 0.91)

Carfilzomib group

 Kd

PFS

Log-normal: meanlog = 2.72; sdlog = 1.48

[5, 10, 33, 34]

OS

Exponential: rate = 0.01513

 DKd

HR of PFS

0.59 (0.45 – 0.78)

[5, 10]

HR of OS

0.78 (0.62 – 0.94)

 IsaKd

HR of PFS

0.58 (0.42 – 0.79)

[33, 34]

HR of OS

0.78 (0.61 – 0.95)

 Pd

OS

Gamma: shape = 1.2023, 0.04114