Fig. 2

(A) progression-free survival (PFS) for patients in the ORIENT-15 trial; (B) progression-free survival (PFS) for the model-estimated data; (C) OS for patients in the ORIENT-15 trial; (D) overall survival (OS) for the model-estimated data; (E) in terms of the median OS and PFS, the simulated results were consistent with the empirical data from the ORIENT-15 trial; Sin-Che, sintilimab-chemotherapy; Pla-Che, placebo-chemotherapy; OS, overall survival; PFS, progression-free survival