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Table 1 Description of the variables referring to the healthcare costs tracked during the follow-up: type of healthcare service, time window considered, name, definition and diagnostic/therapeutic codes. Time window labelled as “pre” refers to the period from the conception to the delivery; “Post” refers to the period from the delivery to the year after. ATC: anatomical therapeutic chemical classification system. ED: emergency department. ICD-9-CM: international classification of Disease, Ninth Revision, clinical modification

From: Determinants of the economic burden of ART on the Italian NHS: insights from the Lombardy region

Category

Healthcare service

Time window (delivery)

Name

Definition

Diagnostic and therapeutic codes

General

Specialistic services

Pre

General_visits_pre

Total cost of all outpatient visits during pregnancy

All codes

Post

General_visits_post

Total cost of all outpatient visits after delivery

All codes

Pharmaceutical prescriptions

Pre

General_drugs_pre

Total cost of all drugs prescribed during pregnancy

All codes

Post

General_drugs_post

Total cost of all drugs prescribed used after delivery

All codes

Hospital admissions

Pre

General_hospital_pre

Total cost of all hospital admissions experienced during pregnancy

All codes

Post

General_hospital_post

Total cost of all hospital admissions experienced after delivery

All codes

ED admissions

Pre

General_ED_pre

Total cost of all ED admissions experience during pregnancy

All codes

Post

General_ED_post

Total cost of all ED admissions experiences after delivery

All codes

Pregnancy

Specialistic services

Pre

Pregnancy_visits_pre

Total cost of outpatient visits related to pregnancy (e.g., amniocentesis, obstetric ultrasound, prenatal training, etc.)

ICD-9-CM codes:

75.10.1, 75.10.2, 75.10.3, 75.33.1, 75.34.1, 88.78, 88.75.2, 89.26.4, 93.37

Post

Pregnancy_visits_post

Total cost of outpatient visits related to the post-partum state (i.e., gynecological visits)

ICD-9-CM codes:

88.78.2, 88.79.7, 89.26.1, 89.26.2

Pharmaceutical prescriptions

Pre

Pregnancy_drugs_pre

Total cost of acid folic prescriptions during pregnancy

ATC codes:

B03BB

Hospital admissions

Post

Pregnancy_hospital_post

Total cost of the hospital admission related to the delivery

ICD-9-CM diagnostic codes:

V27, 640.−676., ICD-9-CM procedures codes:

72., 732.,735.,736., 738.−742., 744., 749.9

DRG codes: 370–375

Complications

Hospital admissions

Pre

Complications_hospital_pre

Total cost of the hospital admission for complications related to pregnancy (e.g., antepartum haemorrhage, hypertension disorders, gestation diabetes, etc.)

ICD-9-CM diagnostic codes:

640.−649.

Post

Complications_hospital_post

Total cost of the hospital admission for complications related to post-partum state (e.g., major puerperal infection, complications of venous thromboembolism, etc.)

ICD-9-CM diagnostic codes:

670.−677.

Specialistic services

Post

Complications_visits_post

Total cost of outpatient visits related to complications of the post-partum state (e.g., other dilation or curettage of the uterus, etc.)

ICD-9-CM codes:

75.8, 68.12.1, 69.09

Pharmaceutical prescriptions

Pre

Complications_drugs_diabetes_pre

Total cost of antidiabetic drugs prescribed during pregnancy

ATC codes: A10

Complications_drugs_hypertension_pre

Total cost of antihypertensive drugs prescribed during pregnancy

ATC codes: C02

Complications_drugs_heparin_pre

Total cost of heparin drugs prescribed during pregnancy

ATC codes: B01

Complications_drugs_antibiotics_pre

Total cost of antibiotics drugs prescribed during pregnancy

ATC codes: J01

Post

Complications_drugs_hypertension_post

Total cost of antihypertensive drugs prescribed after delivery

ATC codes: C02

Complications_drugs_heparin_post

Total cost of heparin drugs prescribed after delivery

ATC codes: B01

Complications_drugs_antibiotics_post

Total cost of antibiotics drugs prescribed after delivery

ATC codes: J01

Practices

Pharmaceutical prescriptions

Pre

Practices_progestogen_pre

Total cost of progestogen prescribed after the third month of pregnancy

ATC codes: G03D

Practices_cardioaspirin_pre

Total cost of cardioaspirin prescribed before delivery

ATC codes: B01AC06, B01AC56