Table 3 Dosing schedules and costs for each patient in a 6-month chemotherapy cycle

Guideline

130 mg/m²

850 mg/m²

First = 8 mg/kg,

other = 6 mg/kg

400 mg/m²

85 mg/m²

400 mg/m²

Dose per administration¹

223.6 mg

1462 mg

First: 520 mg

Other: 390 mg

688 mg

146.2 mg

Bulus: 689 mg

Maintenance dose: 4134

Total = 4823 mg

Total drug cost for each cycle ²

Chemotherapy regimen

CAPOX

CAPOX plus Trastuzumab

FOLFOX plus Trastuzumab

FOLFOX

Total cost for each cycle ($)

1129.45

3583.84

5293.71

1659.42

The monthly cost of prescribing four chemotherapy regimens per patient along with the required measures

Item

Private tariff per time ($)

Numbers needed in one chemotherapy cycle

Oncologist visit

6.82

2

Blood tests

15.62

2

CT scan

55.07

1

Cardiologist visit

6.82

2

Echocardiography

21.06

1

Administration of intravenous or arterial chemotherapy with rapid administration technique and infusion method of multiple pre-mixed drugs per cycle up to 8 h.

12.43

2

Preparation of chemotherapy injection solutions (bulky and non-bulky) (cytotoxic drugs compounding)

18.12

2

Average monthly cost

116.64

The average monthly cost of each chemotherapy regimen (including drug costs and other services associated with drug prescription)

CAPOX

CAPOX + Trastuzumab

FOLFOX

FOLFOX + Trastuzumab

244.97

713.95

276.57

882.28