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Table 2 Basic characteristics of the included studies

From: Systematic review of the economic evaluation model of assisted reproductive technology

Studies included

Countries

Perspective

Study population

Comparators

Evans 2019 [13]

US

—

Patients receiving fresh/frozen embryo transfer

Different ovulation agents:

â‘ Progesterone:

â‘¡Conventional GnRH

Xue 2019 [14]

Germany

Payer

Patients during an assisted reproductive cycle

Different ovulation agents:

â‘ r-FSH:

â‘¡r-FSH biosimilars

Oostingh 2019 [15]

Netherlands

â‘ Health system;

â‘¡The whole society

Low fertility couples undergoing IVF for the first time

Different pre-pregnancy care:

â‘ mHealth coaching program;

â‘¡Usual care

Jing 2020 [16]

China

Patient

Patients aged 20 to 38 years undergoing their first IVF cycle

Different ovulation induction regiments:

â‘ GnRH-a long-protocol;

â‘¡GnRH-A protocol

Kluber 2020 [17]

Germany

Patient

Women who plan to delay pregnancy until after the age of 40

Different interventions:

â‘ oocyte cryopreservation;

â‘¡natural conception;â‘¢IVF/ICSI

Mathieu 2020 [18]

France

—

Women younger than 40 years of age diagnosed with endometriosis and referred for family planning

Different ovulation induction regiments:

â‘  PPOS protocol;

â‘¡antagonist protocol

Sitler 2020 [19]

US

â‘ Patient;

â‘¡Payer

Patients aged 20 to 44 undergoing IVF

Different transfer protocols:

â‘  SET;

â‘¡ DET

Facadio 2021 [20]

US

Payer

Patients undergoing IVF treatment with fresh donor oocytes

PGT-A

Lee 2021 [21]

US

â‘ Patient;

â‘¡Payer

Women over 18 years of age undergoing their first fresh IVF/ frozen embryo transfer cycle

PGT-A

van Eekelen 2021 [22]

Netherlands

The whole society

Couples with unexplained low fertility

Different ovulation agents:

â‘  CC;

â‘¡Letrozole;

â‘¢Gonadotrophins

Cheng 2021 [23]

US

—

Couples who have undergone vasectomy reversal (couples with advanced maternal age)

Different treatment options:

â‘ VR followed by NC;

â‘¡SR with IVF;

â‘¢VR and SR followed by failed NC and then IVF;

â‘£VR and SR followed by failed IVF and then NC

Schwarze 2022 [24]

Spain

Health system

Fresh embryo transfer in patients with ART cycles

Different ovulation agents:

①Originator r-hFSHα;

②r-hFSHα biosimilars

  1. Note: — represents what is not explained in the text (the same below)
  2. CC: clomiphene citrate, DET: double embryo transfer, FSH: follicle stimulating hormone, GnRH: gonadotropin-releasing hormone, GnRH-a: gonadotropin-releasing hormone-agonist, GnRH-A: gonadotropin-releasing hormone-antagonist, ICSI: intracytoplasmic sperm injection, IVF: in vitro fertilization, NC: natural conception, PGT-A: preimplantation genetic testing for aneuploidy, PPOS: progestin-primed ovarian stimulation, r-FSH: recombinant follicle stimulating hormone, r-hFSHα: recombinant human follicle stimulating hormone alfa, SET: single embryo transfer, SR: sperm retrieval, US: united states, VR: vasectomy reversal