Pancreatic stone protein point-of-care testing can reduce healthcare expenditure in sepsis

Health Economics Review

Table 2 Baseline clinical inputs

Parameter	Standard of Care	Rapid PSP	Source
Base Parameters
Length of stay on the regular ward (days; TP)^a	6.5		Average of Mewes 2019, Balk 2017 [23, 25]
Length of stay in the ICU (days; TP)^a	10.6		Average of Voermans 2019, Mewes 2019, Balk 2017 [23,24,25]
Antibiotic days of therapy	19.0		Average of Voermans 2019, Balk 2017 [24, 25]
Emergency Department
Incidence of sepsis among patients presenting with infection	41%		Rhee 2017 [3]
30-day readmission for infection	20%		Broyles 2017 [30]
Patients admitted to the ICU	8%		Broyles 2017 [30]
Intensive Care Unit
Incidence of sepsis among patients	77%		Average of Vincent 2009, Johnson 2018 [31, 32]
30-day readmission for infection	28%		Bishop 2014 [33]
Sensitivity & Specificity
Test sensitivity	34%	85%	PSP: Average of Llewelyn 2013, Garcia de Guadiana-Romualdo 2017 [21, 28]; SOC: Singer 2014 [34]
Test specificity	82%	80%	PSP: Average of Llewelyn 2013, Garcia de Guadiana-Romualdo 2017 [21, 28]; SOC: Singer 2014 [34]
Antibiotic Resistance (ABR)
Prevalence of ABR	19.40%		Burnham 2015 [9]
Percent Reduction in ABR per percent reduced antibiotic days	3.20%		Mewes 2019 [23]
Additional length of stay due to ABR^a	4.6		Mewes 2019; Voermans 2019 [23, 24]
*Clostridium difficile* infection (CDI)
Prevalence of CDI	3%		Mewes 2019 [23]
Additional length of stay due to CDI	5.85		Average of Mewes 2019, Voermans 2019 [23, 24]

^aValue represents the baseline input; additional calculations specific to diagnostic arm were applied as described in the “Methods” section

ISSN: 2191-1991