Exploratory cost-effectiveness analysis of cardiac resynchronization therapy with systematic device optimization vs. standard (non-systematic) optimization: a multinational economic evaluation

Table 3 Base case results by treatment group (systematic vs. standard CRT-P optimization) from the perspective of the healthcare payer (values represent discounted average per-patient outcomes)

Country	1 year	2 years	3 years	4 years	5 years
Germany
Total cost – systematic optimization group	€ 15,120	€ 16,143	€ 17,063	€ 17,897	€ 18,625
Total cost – standard optimization group	€ 13,532	€ 14,769	€ 15,896	€ 16,930	€ 17,832
Increment (systematic vs. standard)	€ 1,588	€ 1,375	€ 1,168	€ 967	€ 793
Total QALYs – systematic optimization group	0.71	1.32	1.85	2.32	2.72
Total QALYs – standard optimization group	0.64	1.19	1.65	2.05	2.39
Increment (systematic vs. standard)	0.07	0.13	0.21	0.27	0.33
ICER^a	€ 26,973	€ 10,224	€ 5,690	€ 3,556	€ 2 371
France^b
Incremental total cost (systematic vs. standard)	€ 1,357	€ 971	€ 596	€ 232	€ −88
Incremental total QALYs (systematic vs. standard)	0.07	0.13	0.21	0.27	0.33
ICER	€ 23,053	€ 7,222	€ 2,904	€ 853	Dominant
Spain^b
Incremental total cost (systematic vs. standard)	€ 1,309	€ 943	€ 587	€ 242	€ −61
Incremental total QALYs (systematic vs. standard)	0.07	0.13	0.21	0.27	0.33
ICER	€ 22,226	€ 7,010	€ 2,862	€ 892	Dominant
Italy^b
Incremental total cost (systematic vs. standard)	€ 1,588	€ 1,333	€ 1,076	€ 820	€ 594
Incremental total QALYs (systematic vs. standard)	0.07	0.13	0.21	0.27	0.33
ICER	€ 26,977	€ 9,912	€ 5,244	€ 3,017	€ 1 775
UK^b
Incremental total cost (systematic vs. standard)	£ 1,224	£ 993	£ 770	£ 554	£ 367
Incremental total QALYs (systematic vs. standard)	0.07	0.13	0.21	0.27	0.33
ICER	£ 20,787	£ 7,405	£ 3,771	£ 2,055	£ 1,109

ISSN: 2191-1991