Table 2 Results of the reviewed studies
From: Genome sequencing: a systematic review of health economic evidence
Author (publication year) | Throughput Mb/day | Bases/read | Raw accuracy | Cost per instrument | Cost per Mb approximately | |
|---|---|---|---|---|---|---|
Sanger | Kircher et al. (2010) | 6 | 800 | 0.99991 | - | $500.00 |
Roche/454 GS FLX Titanium | Shendure et al. (2008) | - | 250 | - | $500 000 | $60.00 |
Tucker et al. (2009) | 1 200 | 400 | 0.99 | - | $84.40 | |
Kircher et al. (2010) | 750 | 400 | 0.9991 | - | $20.00 | |
Glenn (2011) | - | 400 | 0.99 | - | $12.40 | |
Pareek et al. (2011) | 1 000 | 400 | 0.995 | $500 000 | $84.39 | |
Illumina Genome Analyzer II/IIx | Tucker et al. (2009) | 2 500 | 75+ | 0.985 | - | $6.00 |
Kircher et al. (2010) | 5 000 | 100 | 0.991 | - | $0.50 | |
Illumina Solexa | Shendure et al. (2008) | - | 36 | - | $430 000 | $2.00 |
Pareek et al. (2011) | 1 500 | 36 | 0.985 | $400 000 | $5.97 | |
Illumina HiSeq 2000 | Glenn (2011) | - | 100 + 100 | 0.99 | - | $0.10 |
Applied Biosystems SOLiD 4 | Shendure et al. (2008) | - | 35 | - | $591 000 | $2.00 |
Pareek et al. (2011) | 1 850 | 35 | 0.9994 | $525 000 | $5.81 | |
Tucker et al. (2009) | 2 500 | 50 | 0.994 | - | $5.80 | |
Kircher et al. (2010) | 5 000 | 50 | 0.991 | - | $0.50 | |
Life Technologies SOLiD 5500 | Glenn (2011) | - | 75 + 35 | 0.99 | - | <$0.08 |
Life Technologies SOLiD 5500xl | Glenn (2011) | - | 75 + 35 | 0.99 | - | <$0.07 |
Helicos HeliScope | Shendure et al. (2008) | - | 30 | - | $1 350 000 | $1.00 |
Tucker et al. (2009) | 3 100 | 30-35 | 0.99 | - | - | |
Kircher et al. (2010) | 5 000 | 32 | 0.99 | - | $0.50 | |
Glenn (2011) | - | 35 | - | - | - | |
Pareek et al. (2011) | 2 500 | >1000 | >0.99 | - | - | |
Polonator | Shendure et al. (2008) | - | 13 | - | $155 000 | $1.00 |